Phenotypes Associated with This Genotype

Genotype
MGI:3714773

• Allelic Composition: Bmal1^tm1Bra/Bmal1^tm1Bra; Tg(Scg2-tTA)1Jt/0; Tg(tetO-Arntl)1Jt/0
• Genetic Background: involves: 129/Sv * C57BL/6J * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:116189 )

N • rescued mice exhibit a consistent circadian rhythm (without doxycycline-treatment) which is abolished within 1 to 2 days of doxycycline treatment, then regained after doxycycline withdrawal

abnormal locomotor activation ( J:116189 )

• although circadian rhythm is restored, level activity and amplitude are significantly lower than observed in wild-type

shortened circadian behavior period ( J:116189 )

• free-running period of rescued mice (bitransgenic null mice without doxycycline treatment) is about 1 hour shorter than in wild-type