About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3714525
Allelic
Composition		 KitW/KitW
Tg(PDGFB-EPO)321Zbz/?
Genetic
Background		 involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
KitW mutation (10 available); any Kit mutation (180 available)
Tg(PDGFB-EPO)321Zbz mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:79128 )
• thymic TN-1 cells are lacking
abnormal B cell differentiation ( J:79128 )
• severe block to T cell and B cell development is similar to that seen in KitW-vkd homozygotes
abnormal T cell differentiation ( J:79128 )
• severe block to T cell and B cell development is similar to that seen in KitW-vkd homozygotes
decreased B cell number ( J:79128 )
• bone marrow fraction B cells are lacking

immune system
decreased thymocyte number ( J:79128 )
• thymic TN-1 cells are lacking
abnormal B cell differentiation ( J:79128 )
• severe block to T cell and B cell development is similar to that seen in KitW-vkd homozygotes
abnormal T cell differentiation ( J:79128 )
• severe block to T cell and B cell development is similar to that seen in KitW-vkd homozygotes
decreased B cell number ( J:79128 )
• bone marrow fraction B cells are lacking

endocrine/exocrine glands
decreased thymocyte number ( J:79128 )
• thymic TN-1 cells are lacking

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory