Phenotypes Associated with This Genotype

Genotype
MGI:3714524

• Allelic Composition: Kit^W-vkd/Kit^W-vkd
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * WB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased thymocyte number ( J:79128 )

• CD25+ thymocytes are severely decreased in aged mice from a 5-fold reduction at 28 days to 1000-fold reduction in aged mice

• thymic lymphoid cells are reduced 25-fold compared to wild-type

abnormal B cell differentiation ( J:79128 )

• B cell progenitors are lost

abnormal T cell differentiation ( J:79128 )

• lymphoid progenitors are depleted

decreased bone marrow cell number ( J:79128 )

• cellularity is reduced by 1.4-fold

low mean erythrocyte cell number ( J:79128 )

• mice only have 30% of red blood cell numbers found in wild-type mice

decreased B cell number ( J:79128 )

• at 198 days, B cell progenitors are almost undetectable

• however, at younger ages B cell development is normal

• mice lack B cell fractions C (B220+CD43+CD24+BP-1+), D (B220+CD43-IgM-) and E (B2200+CD43-IgM+) in the bone marrow bone marrow fraction B cells are lacking

immune system

decreased thymocyte number ( J:79128 )

• CD25+ thymocytes are severely decreased in aged mice from a 5-fold reduction at 28 days to 1000-fold reduction in aged mice

• thymic lymphoid cells are reduced 25-fold compared to wild-type

abnormal B cell differentiation ( J:79128 )

• B cell progenitors are lost

abnormal T cell differentiation ( J:79128 )

• lymphoid progenitors are depleted

decreased B cell number ( J:79128 )

• at 198 days, B cell progenitors are almost undetectable

• however, at younger ages B cell development is normal

• mice lack B cell fractions C (B220+CD43+CD24+BP-1+), D (B220+CD43-IgM-) and E (B2200+CD43-IgM+) in the bone marrow bone marrow fraction B cells are lacking

endocrine/exocrine glands

decreased thymocyte number ( J:79128 )

• CD25+ thymocytes are severely decreased in aged mice from a 5-fold reduction at 28 days to 1000-fold reduction in aged mice

• thymic lymphoid cells are reduced 25-fold compared to wild-type