Phenotypes Associated with This Genotype

Genotype
MGI:3714516

• Allelic Composition: Nkd1^tm1Kwha/Nkd1^tm1Kwha; Nkd2^tm1Kwha/Nkd2^tm1Kwha
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:122353 )

N • mice are viable and fertile

behavior/neurological

pup cannibalization ( J:122353 )

♀ • significantly higher rate of cannabilization of offspring prior to weaning is observed in females having no or one wild-type copy of Nkd1 or Nkd2 (35% of 46 litters of females with one or no wild-type copies of either allele compared to only 14% of 51 litters of Nkd1-null or Nkd2-null homozygous females)

craniofacial

decreased cranium height ( J:122353 )

• at 2 months, skulls of mice are slightly shortened

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

skeleton

decreased cranium height ( J:122353 )

• at 2 months, skulls of mice are slightly shortened

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

growth/size/body

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls

respiratory system

short nasal bone ( J:122353 )

• at 2 months, nasal bones are slightly shortened relative to controls