Phenotypes Associated with This Genotype

Genotype
MGI:3714510

• Allelic Composition: Myf6^tm1Eno/Myf6^tm1Eno; Myod1^tm1Jae/Myod1^tm1Jae
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:48809 )

• die within minutes after birth due to an inability to breathe

growth/size/body

decreased body size ( J:48809 )

• decrease in body mass at E16.5

muscle

centrally nucleated skeletal muscle fibers ( J:48809 )

• nuclei are centrally located instead of in the periphery as in wild-type

decreased skeletal muscle fiber number ( J:48809 )

• severe skeletal muscle deficiency with only residual muscle fibers surrounded by mononucleated cells

absent skeletal muscle ( J:48809 )

• appear to lack skeletal muscle beginning at E14.5

skeleton

abnormal rib morphology ( J:48809 )

• show rib defects indistinguishable from Myf6^tm1Eno homozygotes

kyphosis ( J:48809 )

• show abnormal curvature of the spine starting around E14.5

adipose tissue

abnormal adipose tissue distribution ( J:48809 )

• accumulate brown fat at the apex of the neck beginning at E14.5

respiratory system

respiratory failure ( J:48809 )

• die within minutes after birth due to an inability to breathe