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Phenotypes Associated with This Genotype
Genotype
MGI:3714384
Allelic
Composition		 Hc0/Hc0
Genetic
Background		 B10.D2-Hc0
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hc0 mutation (28 available); any Hc mutation (127 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to injury ( J:120567 )
• mice are resistant to ischemia reperfusion-induced renal injury
• serum urea nitrogen is reduced 35% to 40% compared to wild-type mice subjected to ischemia reperfusion

liver/biliary system
liver fibrosis ( J:100159 )
• resistance to hepatic fibrosis
• less advanced stages of liver fibrosis
• reduced hepatic collagen concentrations

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory