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Phenotypes Associated with This Genotype
Genotype
MGI:3714371
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (3 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• numerous lobular side buds with acinar structures are observed (J:61202)
• numerous lobular side buds with acinar structures are observed (J:61202)
• mice develop precocious lobualveolar hyperplasias of the mammary glands (J:89255)
• mice develop precocious lobualveolar hyperplasias of the mammary glands (J:89255)

tumorigenesis
• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age (J:89255)
• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age (J:89255)

integument
• numerous lobular side buds with acinar structures are observed (J:61202)
• numerous lobular side buds with acinar structures are observed (J:61202)
• mice develop precocious lobualveolar hyperplasias of the mammary glands (J:89255)
• mice develop precocious lobualveolar hyperplasias of the mammary glands (J:89255)

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:167180


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory