Phenotypes Associated with This Genotype

Genotype
MGI:3714349

• Allelic Composition: Trp53^tm2Wahl/Trp53^tm2Wahl
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:174375 )

N • mice exhibit normal lifespan and aging

increased mortality induced by ionizing radiation ( J:174375 )

• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

hematopoietic system

abnormal definitive hematopoiesis ( J:174375 )

• irradiated mice exhibit intra- and extramedullary hematopoiesis that does not compensate for pancytopenia unlike in wild-type mice

decreased common myeloid progenitor cell number ( J:174375 )

• irradiated mice exhibit a more severe decrease in granulocytic/macrophage (CFU-GM) compared with wild-type mice

decreased bone marrow cell number ( J:174375 )

• after irradiation, mice exhibit atrophy of hematopoietic cells in the bone marrow compared with similarly treated wild-type mice

decreased erythroid progenitor cell number ( J:174375 )

• irradiated mice exhibit a more severe decrease in erythroid (BFU-E) compared with wild-type mice

abnormal megakaryocyte progenitor cell morphology ( J:174375 )

• irradiated mice exhibit a more severe decrease in megakaryocytic (CFU-MK) compared with wild-type mice

decreased erythrocyte cell number ( J:174375 )

• slightly prior to irradiation

• after irradiation

decreased hematocrit ( J:174375 )

• in irradiated mice

thrombocytopenia ( J:174375 )

• slightly prior to irradiation

• after irradiation

decreased leukocyte cell number ( J:174375 )

• slightly prior to irradiation

• after irradiation

decreased spleen red pulp amount ( J:174375 )

• after irradiation

abnormal hematopoietic stem cell physiology ( J:174375 )

• hematopoietic stem cells compete poorly with wild-type cells in transplantation assays and are more sensitive to irradiation compared with wild-type cells

cardiovascular system

enlarged heart ( J:174375 )

• in irradiated mice

increased heart weight ( J:174375 )

• in irradiated mice

integument

pallor ( J:174375 )

• in irradiated mice

immune system

decreased leukocyte cell number ( J:174375 )

• slightly prior to irradiation

• after irradiation

decreased spleen red pulp amount ( J:174375 )

• after irradiation

homeostasis/metabolism

increased mortality induced by ionizing radiation ( J:174375 )

• all mice die within 4 weeks of irradiation unlike similarly treated wild-type mice

growth/size/body

enlarged heart ( J:174375 )

• in irradiated mice

increased heart weight ( J:174375 )

• in irradiated mice