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Phenotypes Associated with This Genotype
Genotype
MGI:3714319
Allelic
Composition		 Espl1tm1.1Tno/Espl1tm1.2Tno
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Tno mutation (0 available); any Espl1 mutation (92 available)
Espl1tm1.2Tno mutation (0 available); any Espl1 mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell nucleus size ( J:107917 )
• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) have enlarged nuclei
decreased cell proliferation ( J:107917 )
• following treatment with Cre-adenovirus, mouse embryonic fibroblasts (MEFs) exhibit growth retardation
• DNA replication continues to occur
• however, infection with Cre-adenovirus can reduce some growth in the absence of floxed alleles

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory