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Phenotypes Associated with This Genotype
Genotype
MGI:3714277
Allelic
Composition		 Cd80tm1Shr/Cd80tm1Shr
Cd86tm2Shr/Cd86tm2Shr
Tg(Ighm-Ctla4Ig/Cd80)1Jbs/0
Genetic
Background		 involves: 129S4/SvJae * FVB/N * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd80tm1Shr mutation (12 available); any Cd80 mutation (42 available)
Cd86tm2Shr mutation (3 available); any Cd86 mutation (38 available)
Tg(Ighm-Ctla4Ig/Cd80)1Jbs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
insulitis ( J:113109 )
• mice show less insulitis compared to non-transgenic double nulls
decreased regulatory T cell number ( J:113109 )
• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls
decreased susceptibility to autoimmune diabetes ( J:113109 )
• mice show 40% suppression of diabetes development compared to non-transgenic double null animals

hematopoietic system
decreased regulatory T cell number ( J:113109 )
• mice have 0.3% CD4+CD25hiCD62L+ regulatory T cells compared to 4% in NOD controls

endocrine/exocrine glands
insulitis ( J:113109 )
• mice show less insulitis compared to non-transgenic double nulls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory