Phenotypes Associated with This Genotype

Genotype
MGI:3714175

• Allelic Composition: Tg(Camk2a-Crebbp*)1364Tabe/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:121812 )

N • mutants show normal short-term memory and cued fear conditioning relative to control littermates

abnormal contextual conditioning behavior ( J:121812 )

• in foot shock paradigm, upon re-exposure to conditioned context 24 hours after training, mutants show decreased freezing compared to wild-type littermates

abnormal spatial learning ( J:121812 )

• mice show deficit in spatial learning, with significant impairment in acquisition of Morris water maze hidden platform task; mean escape latency is lower in wild-type mice, whereas transgenic mice reach a plateau on fifth day of training; wild-type mice show a preference for the target quadrant relative to transgenic mice

increased thigmotaxis ( J:121812 )

• mutants display increased thigmotaxis (swimming in outer 10% of pool) during training compared to littermate controls

nervous system

reduced long-term potentiation ( J:121812 )

• in hippocampal slices treated with the D1 dopaminergic agonist chloro-APB followed by a single 1 second, 100 Hz train stimulus, average potentiation is significantly at 60 minutes relative to wild-type