Analysis Tools
mortality/aging
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• pups die within a few hours of birth
|
homeostasis/metabolism
|
• free fatty acids and ceramide content are decreased in the outer layer of the epidermis
|
|
• skin on the limbs, tail and parts of the head show increased permeability
• however, skin on the body does not show increased permeability
|
|
• cholesterol levels are mildly increased in the outer layer of the epidermis
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growth/size/body
weight loss
(
J:122320
)
|
• mice loose as much as 5% of their weight within 3 hours of birth
|
skeleton
| N |
• in contrast to Chuktm1.1Mpa homozygotes, mice do not have any skeletal abnormalities
|
integument
|
• skin on the limbs, tail and parts of the head show increased permeability
• however, skin on the body does not show increased permeability
|
|
• epidermis had increased vascularisation
• blood vessel diameter is increased within the epidermis
|
|
• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo
|
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• free fatty acids and ceramide content are decreased in the outer layer of the epidermis
• lipid composition within the stratum corneum is altered resulting in defective epidermal barrier and increased transepidermal water loss
|
shiny skin
(
J:122320
)
|
• at birth skin is shiny, sticky and taut
|
cellular
|
• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo
|
