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Phenotypes Associated with This Genotype
Genotype
MGI:3714032
Allelic
Composition		 Ryr2tm1.1Msnr/Ryr2+
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ryr2tm1.1Msnr mutation (1 available); any Ryr2 mutation (325 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal heart morphology ( J:122033 )
• small decrease in the cross-sectional area of septal and left ventricular cadiomyocytes
enlarged heart ( J:122033 )
• at day 1, mice have a slightly higher ratio of heart weight to body weight compared with wild-type
• however, at day 7 and 10 heart to body weight ratios are normal

growth/size/body
enlarged heart ( J:122033 )
• at day 1, mice have a slightly higher ratio of heart weight to body weight compared with wild-type
• however, at day 7 and 10 heart to body weight ratios are normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory