Phenotypes Associated with This Genotype

Genotype
MGI:3713920

• Allelic Composition: Myf5^{tm1(Pdgfa)Sor}/Myf5^{tm1(Pdgfa)Sor}
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:65301 )

• animals die at birth

skeleton

abnormal thoracic cage morphology ( J:65301 )

• increased rib development leads to substantial rib cage formation relative to Myf5 null mice

abnormal rib morphology ( J:65301 )

• animals have multiple ribs touching the sternum compared to Myf5^tm1Jae homozygotes; rib formation is most extensive in distal part abutting the sternum

increased rib number ( J:65301 )

• supernumerary rib structures that are either floating or linke to other ribs in anterior to posterior direction are observed

fusion of vertebral arches ( J:65301 )

• mutants show very few vertebral arch fusions compared to Myf5^tm1Jae homozygotes