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Phenotypes Associated with This Genotype
Genotype
MGI:3713804
Allelic
Composition		 Rbpjtm1Hon/Rbpjtm1Hon
Tg(Pax2-cre)1Akg/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpjtm1Hon mutation (2 available); any Rbpj mutation (193 available)
Tg(Pax2-cre)1Akg mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:119907 )
• embryos are normal at E12.5, but die at E13.5

renal/urinary system
absent podocytes ( J:119907 )
• podocytes with WT1high expression do not develop in E12.5 cultures
abnormal proximal convoluted tubule morphology ( J:119907 )
• cultured E12.5 mtanephroi branch normally, but tubules positive for LTL (lectin) are not detected

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory