Phenotypes Associated with This Genotype

Genotype
MGI:3713804

• Allelic Composition: Rbpj^tm1Hon/Rbpj^tm1Hon; Tg(Pax2-cre)1Akg/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119907 )

• embryos are normal at E12.5, but die at E13.5

renal/urinary system

absent podocytes ( J:119907 )

• podocytes with WT1^high expression do not develop in E12.5 cultures

abnormal proximal convoluted tubule morphology ( J:119907 )

• cultured E12.5 mtanephroi branch normally, but tubules positive for LTL (lectin) are not detected