Phenotypes Associated with This Genotype

Genotype
MGI:3713687

• Allelic Composition: Notch2^tm1Yha/Notch2⁺
• Genetic Background: B6.129-Notch2^tm1Yha

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B-1 B cell number ( J:85379 )

• reduction in B-1 B cells of the peritoneal cavity

abnormal spleen marginal zone morphology ( J:85379 )

• impaired development of marginal zone B cells results in a severe reduction in marginal zone B cells of the spleen

• however, splenic architecture is grossly normal

decreased marginal zone B cell number ( J:85379 )

• severe reduction in marginal zone B cells of the spleen

hematopoietic system

decreased B-1 B cell number ( J:85379 )

• reduction in B-1 B cells of the peritoneal cavity

abnormal spleen marginal zone morphology ( J:85379 )

• impaired development of marginal zone B cells results in a severe reduction in marginal zone B cells of the spleen

• however, splenic architecture is grossly normal

decreased marginal zone B cell number ( J:85379 )

• severe reduction in marginal zone B cells of the spleen