Phenotypes Associated with This Genotype

Genotype
MGI:3713466

• Allelic Composition: Pygo2^tm1.2Ssp/Pygo2^tm1.2Ssp; Tg(CMV-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121918 )

• mice are born but with rare exceptions die shortly afterwards

renal/urinary system

abnormal kidney morphology ( J:121918 )

• at high penetrance

abnormal ureter development ( J:121918 )

• at E18.5, mesenchyme surrounding the ureteric buds is thickened 30% and ureteric tips are dilated and misshaped

• however, nephrogenesis is normal

vision/eye

aphakia ( J:121918 )

• at high penetrance

growth/size/body

cleft palate ( J:121918 )

• at low penetrance

decreased fetal size ( J:121918 )

• at high penetrance

fetal growth retardation ( J:121918 )

• at high penetrance

nervous system

exencephaly ( J:121918 )

• at low penetrance

craniofacial

cleft palate ( J:121918 )

• at low penetrance

digestive/alimentary system

cleft palate ( J:121918 )

• at low penetrance