Phenotypes Associated with This Genotype

Genotype
MGI:3713364

• Allelic Composition: Gabra1^tm1.1Geh/Gabra1^tm1.1Geh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal inhibitory postsynaptic currents ( J:70505 , J:103381 )

• at P35, whole-cell patch-clamp recordings of miniature inhibitory postsynaptic currents (mIPSCs) in cerebellar stellate neurons indicate that mutant mIPSC amplitude is significantly reduced and decay is significantly longer relative to that observed in wild type neurons (J:70505)

• at P11, mIPSCs amplitude is already significantly reduced in mutant cerebellar stellate neurons; however, the decay rate is not significantly slower relative to wild-type neurons (J:70505)

• zolpidem is significantly less efficacious in prolonging the duration of mIPSCs in mutant stellate neurons (J:70505)

• at P35, most mutant cerebellar granule neurons do not present low-frequency spontaneous IPSCs (sIPSCs); when recorded, mutant sIPSCs are significantly longer than those observed in wild-type granule neurons (J:70505)

• mice exhibit a 50% to 60% decrease in miniature inhibitory postsynaptic current (mIPSC) in interneurons and pyramidal cells compared to wild-type cells (J:103381)

• mIPSC amplitude in neurons is decreased 20% and decay time is increased 59% in interneurons and 44% in pyramidal cells compared to in wild-type cells (J:103381)

• zolpidem fails to increase mIPSC amplitude or frequency in interneurons or pyramidal cells unlike in similarly treated wild-type mice (J:103381)

• zolpidem fails to increase mean decay time of mIPSCs in interneurons unlike in wild-type cells (J:103381)

• however, zolpidem increases decay time of IPSCs normally in pyramidal cells (J:103381)

• following treatment with zolpidem, peak-scaled non-stationary fluctuations of IPSCs in interneurons do not obtain as high a peak as in wild-type cells (J:103381)

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:103381 )

• zolpidem fails to increase mIPSC amplitude or frequency in interneurons or pyramidal cells unlike in similarly treated wild-type mice

• zolpidem fails to increase mean decay time of mIPSCs in interneurons unlike in wild-type cells

• however, zolpidem increases decay time of IPSCs normally in pyramidal cells

• following treatment with zolpidem, peak-scaled non-stationary fluctuations of IPSCs in interneurons do not obtain as high a peak as in wild-type cells