Analysis Tools
mortality/aging
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• only 15% of expected males reach weaning
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reproductive system
|
N |
• the few surviving males are fertile
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limbs/digits/tail
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• at E12, extra cartilaginous elements are present
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• ectopic ossifications form in 4 of 5 adults typically in the posterior limbs and either attached to or in close proximity to triquatral and harnate bone
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• distal carpal bones are fused
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polydactyly
(
J:110732
)
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• almost exclusively of digits I or II and often associated with syndactyly
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skeleton
|
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• ectopic ossifications form in 4 of 5 adults typically in the posterior limbs and either attached to or in close proximity to triquatral and harnate bone
|
|
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• distal carpal bones are fused
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• at E14.5
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• at E15.5, 2 sternal bands are incomplete
• condensing mesenchyme (collagen2a+) in sternal bands is diffuse and poorly delineated
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• sternebra are fused in 6 of 11 mice
• ossification centers for sternal segments are expanded and fused regardless of proper rib pairing
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• at E18.5, 5 of 11 mice have asymmetric rib pairing
• sternocostal junctions are abnormally positioned and fused in 6 of 11 mice
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• cartilages corresponding to the distal carpal bones are delayed or sometimes impaired
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• ossification centers in the ribs for sternal segments are expanded and fused in 6 of 11 mice
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craniofacial
|
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• at E14.5
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cleft palate
(
J:110732
)
|
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• at E14.5
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homeostasis/metabolism
digestive/alimentary system
cleft palate
(
J:110732
)
|
|
• at E14.5
|
growth/size/body
cleft palate
(
J:110732
)
|
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• at E14.5
|
omphalocele
(
J:110732
)
|
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• at E14.5, the body wall is incompletely closed
|
