Phenotypes for Mfn2 MGI:3713218 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mfn2^tm2Dcc/Mfn2^tm2Dcc
Genetic Background	involves: 129S/SvEv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2^tm2Dcc mutation (0 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial morphology ( J:119702 )

• mouse embryonic fibroblasts (MEFs) derived from homozygotes have predominantly tubular mitochondria in contrast to Mfn2-null cells which have extensive mitochondrial fragmentation; no mitochondrial aggregation is observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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