Phenotypes Associated with This Genotype

Genotype
MGI:3713197

• Allelic Composition: Hes1^tm1Fgu/Hes1^tm1Fgu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal bile duct morphology ( J:151981 )

• mice exhibit biliary agenesis

abnormal bile duct development ( J:151981 )

• the ventral pancreas and biliary primordium do not develop into distinct structures unlike in control mice

abnormal extrahepatic bile duct morphology ( J:151981 )

• hypoplastic

abnormal common bile duct morphology ( J:151981 )

• the common duct is replaced with pancreatic tissue

abnormal pituitary gland development ( J:121843 )

• at E18, here are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is hypoplastic but morphologically normal

abnormal pancreas development ( J:151981 )

• the ventral pancreas and biliary primordium do not develop into distinct structures unlike in control mice

nervous system

abnormal pituitary gland development ( J:121843 )

• at E18, here are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays

pituitary gland hypoplasia ( J:121843 )

• at E18, pituitary gland is hypoplastic but morphologically normal

cellular

abnormal cell differentiation ( J:203419 )

• cultured neural precursor cells have an impaired ability to produce astrocytes

liver/biliary system

abnormal bile duct morphology ( J:151981 )

• mice exhibit biliary agenesis

abnormal bile duct development ( J:151981 )

• the ventral pancreas and biliary primordium do not develop into distinct structures unlike in control mice

abnormal extrahepatic bile duct morphology ( J:151981 )

• hypoplastic

abnormal common bile duct morphology ( J:151981 )

• the common duct is replaced with pancreatic tissue