Analysis Tools
endocrine/exocrine glands
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• enlarged meibomian gland in the absence of doxicycline (transgene is expressed)
• however, the preputial gland and sweat glands are normal
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• hypertrophy of sebaceous glands associated with hair follicles of the eyelids
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vision/eye
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• eyelids show a ring of yellow hair with slightly thicker skin around the eyelashes than seen in wild-type
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• enlarged meibomian gland in the absence of doxicycline (transgene is expressed)
• however, the preputial gland and sweat glands are normal
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limbs/digits/tail
| N |
• in the absence of doxicycline (the transgene is expressed), overall tail morphology is indistinguishable from controls
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integument
| N |
• in the absence of doxicycline (the transgene is expressed), overall skin morphology is indistinguishable from controls
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• enlarged meibomian gland in the absence of doxicycline (transgene is expressed)
• however, the preputial gland and sweat glands are normal
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• hypertrophy of sebaceous glands associated with hair follicles of the eyelids
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• in the absence of doxicycline (the transgene is expressed), guard hair numbers are somewhat increased to 8.7% compared to 5-6% in wild-type
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• in the absence of doxicycline), zigzag hair is reduced to about 6% which is at least 6-fold less than in wild-type
• zigzag hair is not restored when the transgene is turned off in adults by the addition of doxicycline, indicating an irreversible role in embryonic stages
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