Phenotypes Associated with This Genotype

Genotype
MGI:3713120

• Allelic Composition: Atg5^tm1Nmz/Atg5^tm1Nmz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

absence of otoconia (right) or the presence of giant and abnormally shaped otoconial crystals (middle) in the utricle of Atg4b^{Gt(A029E06)Wrst}/Atg4b^{Gt(A029E06)Wrst} mice

nervous system

abnormal brain morphology ( J:110050 )

• neonates have ubiquitin-positive inclusions in a subset of neurons in the pons, dorsal root ganglia, spinal cord, hypothalamus, midbrain and trigeminal ganglia

abnormal adenohypophysis morphology ( J:110050 )

• inclusions are found in the anterior lobe of the pituitary

neuronal intranuclear inclusions ( J:110050 )

• neonates have ubiquitin-positive inclusions in a subset of neurons in the pons, dorsal root ganglia, spinal cord, hypothalamus, midbrain and trigeminal ganglia

• inclusions are time-dependent and are more limited in newborns than in adults

hearing/vestibular/ear

abnormal utricle morphology ( J:163712 )

• mice exhibit an accumulation of eosinophilic globular substance in the utricle unlike in wild-type mice

absent otoliths ( J:163712 )

• in some mice

enlarged otoliths ( J:163712 )

• in some mice

liver/biliary system

abnormal liver morphology ( J:110050 )

• inclusions are found in the liver

abnormal hepatocyte morphology ( J:110050 )

• neonates have ubiquitin-positive inclusions in hepatocytes

endocrine/exocrine glands

abnormal adrenal gland morphology ( J:110050 )

• inclusions are found in the adrenal gland

abnormal adenohypophysis morphology ( J:110050 )

• inclusions are found in the anterior lobe of the pituitary