Phenotypes Associated with This Genotype

Genotype
MGI:3713049

• Allelic Composition: Il4^tm1(CD2)Irvr/Il4⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:111440 )

N • allele activation is initially stochastic; frequency of biallelic expression Il-4 is independent of Il-4 levels but depends on T cell receptor signaling strength

immune system

immune system phenotype ( J:111440 )

N • human CD2 reporter gene is expressed in Th2 and Th0 cells, but not in Th1 cells expressing only IFNgamma; expression is inducible upon T cell activation