Phenotypes Associated with This Genotype

Genotype
MGI:3712984

• Allelic Composition: Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:110201 )

• mice die sooner than wild-type following encephalomyocarditis virus infection

immune system

abnormal cytokine secretion ( J:110201 )

• both naked and transfected polyI:C induced cytokine secretion is reduced 2- to 3-fold

• IFN-alpha, IL-6 and MCP-1 secretion in response to encephalomyocarditis virus infection (EMCV) is abrogated

decreased interferon-alpha secretion ( J:110201 )

• IFN-alpha production following polyI:C induction is abrogated

• IFN-alpha induction by recombinant influenza A with the R38A NS1 mutation, West Nile wirus, Sindbus virus and herpes simplex virus-1 is reduced 2-fold

decreased interleukin-6 secretion ( J:110201 )

• polyI:C induction of IL-6 is reduced in a limited fashion

increased susceptibility to Picornaviridae infection ( J:110201 )

• following encephalomyocarditis virus infection (EMCV), mice develop symptoms of hindlimb paralysis earlier (at 24 to 72 hours) and die sooner

• IFN-alpha, IL-6 and MCP-1 secretion in response to EMCV is abrogated

• however, response to murine cytomegalovirus (MCMV) and reovirus is normal