Phenotypes Associated with This Genotype

Genotype
MGI:3712961

• Allelic Composition: Kmt2a^{tm2(MLLT3)Thr}/Kmt2a^{tm2(MLLT3)Thr}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal blood cell morphology/development ( J:110241 )

• immature cells are found in the blood

abnormal definitive hematopoiesis ( J:110241 )

• bone marrow myeloid pro-B cell colony forming units in vivo are significantly higher than in wild-type and Mll1^tm1(AFF1)Ksy

• predominantly type I myeloid colonies are found

increased pro-B cell number ( J:110241 )

• pro-B cell colony forming units in vivo are significantly higher than in wild-type mice

increased leukocyte cell number ( J:110241 )

• 7.3x10³+/-1.3x10³/uL compared to 3.9x10³+/-1.0 x10³/uL in wild-type mice

• moribund mice have increased white blood cell counts (225.1 x10³+/-42.4 x10³uL compared to 2.4 x10³+/-0.2 x10³uL in wild-type mice)

increased neutrophil cell number ( J:110241 )

• 7.3x10³+/-1.3x10³/uL compared to 3.9x10³+/-1.0 x10³/uL in wild-type mice

• moribund mice have increased white blood cell counts (225.1 x10³+/-42.4 x10³uL compared to 2.4 x10³+/-0.2 x10³uL in wild-type mice)

neoplasm

increased hemolymphoid system tumor incidence ( J:110241 )

• 37 of 60 mice developed hematologic malignancies with a mean time to development of 220 days

• malignant cells exhibit a varying degree of differentiation from blast cells to cells with maturation into segmented neutrophils

increased leukemia incidence ( J:110241 )

• myeloproliferative disorders (MPD)-like myeloid leukemia is found in moribund mice

• leukemic infiltration of the spleen, bone marrow, liver, lymph nodes, and Peyer patches is observed

increased B cell derived lymphoma incidence ( J:110241 )

• in one moribund mice follicular B-cell lymphoma with myeloid proliferative disorder was observed

craniofacial

short face ( J:110241 )

• mice have short faces

pointed snout ( J:110241 )

big ears ( J:110241 )

• less severe than in Mll1^tm1(AFF1)Ksy homozygotes

growth/size/body

short face ( J:110241 )

• mice have short faces

pointed snout ( J:110241 )

big ears ( J:110241 )

• less severe than in Mll1^tm1(AFF1)Ksy homozygotes

decreased body size ( J:110241 )

• mice are small at birth

decreased body weight ( J:110241 )

• at 5 weeks, mice weigh 13.6g compared to wild-type mice that weigh 17.4g

immune system

increased pro-B cell number ( J:110241 )

• pro-B cell colony forming units in vivo are significantly higher than in wild-type mice

increased leukocyte cell number ( J:110241 )

• 7.3x10³+/-1.3x10³/uL compared to 3.9x10³+/-1.0 x10³/uL in wild-type mice

• moribund mice have increased white blood cell counts (225.1 x10³+/-42.4 x10³uL compared to 2.4 x10³+/-0.2 x10³uL in wild-type mice)

increased neutrophil cell number ( J:110241 )

• 7.3x10³+/-1.3x10³/uL compared to 3.9x10³+/-1.0 x10³/uL in wild-type mice

• moribund mice have increased white blood cell counts (225.1 x10³+/-42.4 x10³uL compared to 2.4 x10³+/-0.2 x10³uL in wild-type mice)

hearing/vestibular/ear

big ears ( J:110241 )

• less severe than in Mll1^tm1(AFF1)Ksy homozygotes