Mouse Genome Informatics
hm
    Slc26a4pdsm/Slc26a4pdsm
BXA7/PgnJ-Slc26a4pdsm/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Inner ear histology of an Slc26a4pdsm/Slc26a4pdsm mouse

hearing/vestibular/ear
• displacement of Reissner's membrane enlarges the scala media
• reduced or absent hair cells in the inner ear
• malformation of the tectorial membrane
• incomplete turning of the cochlea
• reduced or absent otoconia
• reduction of otoconia in the utricular and saccular maculae
• no response was obtained to 100dB SPL
• completely deaf at 29 and 80 days of age as determined by ABR

reproductive system
N
• male fertility does not appear diminished despite reduced concentration and motility of sperm (J:121997)
• partial testicular atrophy (J:121997)
• reduced total concentration of sperm (J:121997)
• sperm motility is greatly reduced (J:121997)

behavior/neurological

endocrine/exocrine glands
N
• homozygotes do not display any signs of hypothyroidism as assessed by blood serum chemistry of thyroid histology from 4 to 53 weeks of age (J:121997)
• partial testicular atrophy (J:121997)

nervous system
• reduced or absent hair cells in the inner ear
• reduced or absent spiral ganglion cells

Mouse Models of Human Disease
OMIM IDRef(s)
Pendred Syndrome; PDS 274600 J:121997