Phenotypes for Slc26a4 MGI:3712949 MGI Mouse

hearing/vestibular/ear

distended Reissner membrane ( J:121997 )

• displacement of Reissner's membrane enlarges the scala media

abnormal scala media morphology ( J:121997 )

abnormal organ of Corti morphology ( J:121997 )

decreased cochlear hair cell number ( J:121997 )

absent cochlear hair cells ( J:121997 )

• reduced or absent hair cells in the inner ear

abnormal tectorial membrane morphology ( J:121997 )

• malformation of the tectorial membrane

decreased cochlea coiling ( J:121997 )

• incomplete turning of the cochlea

decreased otolith number ( J:121997 )

• reduction of otoconia in the utricular and saccular maculae

absent otoliths ( J:121997 )

• reduced or absent otoconia

increased or absent threshold for auditory brainstem response ( J:121997 )

• no response was obtained to 100dB SPL

deafness ( J:121997 )

• completely deaf at 29 and 80 days of age as determined by ABR

reproductive system

reproductive system phenotype ( J:121997 )

N	• male fertility does not appear diminished despite reduced concentration and motility of sperm

oligozoospermia ( J:121997 )

• reduced total concentration of sperm

asthenozoospermia ( J:121997 )

• sperm motility is greatly reduced

testicular atrophy ( J:121997 )

• partial testicular atrophy

behavior/neurological

head bobbing ( J:121997 )

head tilt ( J:121997 )

circling ( J:121997 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121997 )

N	• homozygotes do not display any signs of hypothyroidism as assessed by blood serum chemistry of thyroid histology from 4 to 53 weeks of age

testicular atrophy ( J:121997 )

• partial testicular atrophy

nervous system