Phenotypes Associated with This Genotype

Genotype
MGI:3712946

• Allelic Composition: Nrp1^tm1Hfu/Nrp1⁺; Nrp2^tm1Mkl/Nrp2^tm1Mkl
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75477 )

• embryos die at E10-10.5, showing longer survival thah double homozygous embryos

embryo

abnormal vitelline vasculature morphology ( J:75477 )

• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks

• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity

• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts

• arterial and venous branching is not seen in yolk sacs at E10

cardiovascular system

abnormal vascular development ( J:75477 )

• embryos show severe vascular impairment at E10

• blood vessels are disorganized, heterogeneous in size, and some show thickening

• blood vessel density is low in the head region, with avascular regions in head and trunk

• small vessel sprouting is seen, but is unconnected to other sprouts and no capillary plexus is formed

abnormal dorsal aorta morphology ( J:75477 )

• dorsal aorta is poorly formed, and outflow tract is undetectable

abnormal vitelline vasculature morphology ( J:75477 )

• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks

• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity

• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts

• arterial and venous branching is not seen in yolk sacs at E10

hemorrhage ( J:75477 )

• multiple hemorrhages are observed in embryos at E10