Phenotypes Associated with This Genotype

Genotype
MGI:3712945

• Allelic Composition: Nrp1^tm1Hfu/Nrp1^tm1Hfu; Nrp2^tm1Mkl/Nrp2⁺
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75477 )

• embryos die at E10-10.5, showing longer survival thah double homozygous embryos

embryo

abnormal vitelline vasculature morphology ( J:75477 )

• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks

• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity

• arterial and venous branching is not seen in yolk sacs at E10

• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts

decreased embryo size ( J:75477 )

• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length

growth/size/body

decreased embryo size ( J:75477 )

• much smaller than littermates; length of embryo in yolk sac is ~50% of control embryo length

cardiovascular system

abnormal vascular development ( J:75477 )

• avascular regions, vessel size heterogeneity, and thickened blood vessels are observed

• outflow tract formation is abnormal

• blood vessel density in head region is slightly higher than in Npr1^tm1Hfu/Npr1⁺; Npr2^tm1Mkl /Npr2^tm1Mkl embryos

abnormal dorsal aorta morphology ( J:75477 )

• abnormal formation of dorsal aorta is observed

abnormal vitelline vasculature morphology ( J:75477 )

• yolk sacs are of normal size, but lack larger collecting vessels and contain irregular and less dense capillary networks

• vasulature of yolk sac at E10 is characterized by vessel heterogeneity, disorganization, and immaturity

• arterial and venous branching is not seen in yolk sacs at E10

• thickened blood vessels, lack of capillaries, and large avascular spaces between blood vessels are observed, with occasional dead-ended sprouts not connected to other sprouts

hemorrhage ( J:75477 )

• multiple hemorrhages are observed in embryos at E10