Phenotypes Associated with This Genotype

Genotype
MGI:3712910

• Allelic Composition: Tg(Myh6-Hod)3Joe/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:121995 )

• mean survival is 32 weeks

cardiovascular system

increased myocardial fiber size ( J:121995 )

• hypertrophied myocytes

enlarged heart ( J:121995 )

• heart to body weight ratio is increased about 25%

cardiac hypertrophy ( J:121677 , J:121995 )

• mice exhibit increasing cardiac hypertrophy (J:121677)

• as early a 3 weeks after birth (J:121995)

abnormal heart ventricle morphology ( J:121995 )

• severe concentric left and right ventricular hypertrophy that progressed variably to cardiac dilatation accompanied by heart failure

thick ventricular wall ( J:121995 )

cardiac fibrosis ( J:121995 )

• at time of death

increased left ventricle diastolic pressure ( J:121995 )

• 5+/-1mmHg compared to 2+/-0.3mmHg in wild-type mice

abnormal systemic arterial blood pressure ( J:121995 )

• impaired diastolic relaxation with no change in systolic blood pressure

congestive heart failure ( J:121995 )

• some mice experience heart failure

muscle

increased myocardial fiber size ( J:121995 )

• hypertrophied myocytes

growth/size/body

enlarged heart ( J:121995 )

• heart to body weight ratio is increased about 25%

cardiac hypertrophy ( J:121677 , J:121995 )

• mice exhibit increasing cardiac hypertrophy (J:121677)

• as early a 3 weeks after birth (J:121995)