Phenotypes Associated with This Genotype

Genotype
MGI:3712811

• Allelic Composition: \Kif11^Gt(XE579)Byg/\Kif11^Gt(XE579)Byg
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, incomplete penetrance ( J:121799 )

• at E3.5, homozygous embryos are found with 7.5% frequency rather than expected 25%

• at E2.5, 16.8% of embryos are homozygous rather than expected 25%

embryonic lethality between implantation and somite formation, complete penetrance ( J:121799 )

• no homozygous embryos are recovered beyond E6.5; only one embryo was identified at E6.5, and it was smaller and partially resorbed

embryo

abnormal preimplantation embryo development ( J:121799 )

• at E3.5, embryos display a range of developmental stages, from 4-cell stage to normal blastocyst stage embryos

failure of morula compaction ( J:121799 )

embryonic growth arrest ( J:121799 )

• embryos appear to have arrested around E3.5; most embryos display fewer cell numbers, some with as few as 4 blastomeres, and most have not undergone compaction

• at E2.5, embryos display an early proliferation defect with most having 4-8 cells compared to most wild-type embryos containing 8-16 cells