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Phenotypes Associated with This Genotype
Genotype
MGI:3712780
Allelic
Composition
Tpmttm1Rlng/Tpmttm1Rlng
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tpmttm1Rlng mutation (0 available); any Tpmt mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• after 10 days treatment with mercaptopurine, mice did not survive as long as wild-type mice

reproductive system
N
• mice are fertile

homeostasis/metabolism
• following thioguanine treatment, thioguanine nucleotide (TGN) levels are increased greater than in Tpmttm1Rlng heterozygotes and wild-type mice
• following mercaptopurine treatment, erythrocyte methylthioinosine monophosphate (MeTIMP) levels cannot be measured unlike in Tpmttm1Rlng heterozygotes and wild-type mice
• after 10 days treatment with mercaptopurine, mice did not survive as long as wild-type mice

hematopoietic system
• after 10 days treatment with thioguanine, all complete blood count variables measured are more profoundly affected than in Tpmttm1Rlng heterozygotes
• after 10 days treatment with mercaptopurine, mice had a higher platelet count than wild-type mice

growth/size/body
• after 10 days treatment with mercaptopurine, mice loss more weight than wild-type mice
• after 10 days treatment with thioguanine, mice lose more weight than Tpmttm1Rlng heterozygotes

Mouse Models of Human Disease
OMIM ID Ref(s)
Thiopurines, Poor Metabolism of, 1; THPM1 610460 J:121737


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory