Mouse Genome Informatics
hm
    Tpmttm1Rlng/Tpmttm1Rlng
involves: 129P2/OlaHsd * C57BL/6 * NMRI
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• after 10 days treatment with mercaptopurine, mice did not survive as long as wild-type mice

reproductive system
N
• mice are fertile (J:121737)

homeostasis/metabolism
• following thioguanine treatment, thioguanine nucleotide (TGN) levels are increased greater than in Tpmttm1Rlng heterozygotes and wild-type mice
• following mercaptopurine treatment, erythrocyte methylthioinosine monophosphate (MeTIMP) levels cannot be measured unlike in Tpmttm1Rlng heterozygotes and wild-type mice
• after 10 days treatment with mercaptopurine, mice did not survive as long as wild-type mice

hematopoietic system
• after 10 days treatment with thioguanine, all complete blood count variables measured are more profoundly affected than in Tpmttm1Rlng heterozygotes
• after 10 days treatment with mercaptopurine, mice had a higher platelet count than wild-type mice

growth/size/body
• after 10 days treatment with mercaptopurine, mice loss more weight than wild-type mice
• after 10 days treatment with thioguanine, mice lose more weight than Tpmttm1Rlng heterozygotes

Mouse Models of Human Disease
OMIM IDRef(s)
Thiopurine S-Methyltransferase Deficiency 610460 J:121737