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Phenotypes Associated with This Genotype
Genotype
MGI:3712657
Allelic
Composition
Cd40lgtm1Imx/Y
Genetic
Background
B6.129S2-Cd40lgtm1Imx/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Imx mutation (4 available); any Cd40lg mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• significantly reduced infarct volumes
• loss of neurons in the submedial thalamic nucleus due to thiamine deficiency slower than in controls
• after 11 days of thiamine deficiency, neuron loss in the submedial thalamic nucleus due to thiamine deficiency is about 90%

hematopoietic system
• reduced leukocyte rolling and adhesion
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

homeostasis/metabolism
• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion
• significantly reduced infarct volumes

cellular
• reduced leukocyte rolling and adhesion

immune system
• reduced leukocyte rolling and adhesion


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory