Phenotypes Associated with This Genotype

Genotype
MGI:3712643

• Allelic Composition: Igh^tm2Mnz/Igh^tm2Mnz
• Genetic Background: B6.129P2-Igh^tm2Mnz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:75653 )

N • 3 and 5 days after immunization, there is no evidence of increased B cell apoptosis relative to wild-type

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)

immune system

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in wild-type

hematopoietic system

increased B cell proliferation ( J:75653 )

• mutant B cells in mice challenged with a T1-2 antigen (NP-Ficoll) undergo rapid proliferative expansion (from 3 to 14% of lymphocytes by 5 days after immunization

• in immunized mice, on day 2 there is a higher percentage of low-affinity B cells (20%) compared to wild-type cells (~3%)

increased IgG level ( J:75653 )

• 4-hydroxy-3-nitrophenyl)acetyl-specific (NP) IgM antibody production is greater than in wild-type

increased IgM level ( J:75653 )

• NP-specific IgM antibody production is greater than in wild-type