Phenotypes Associated with This Genotype

Genotype
MGI:3712449

• Allelic Composition: Tg(WapNotch4)10Rnc/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland growth during pregnancy ( J:33193 )

♀ • gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands

♀ • pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds

♀ • acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina

♀ • in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund

♀ • however, mammary ductal growth is unaffected in virgin females

increased mammary adenocarcinoma incidence ( J:33193 )

• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months

lactation failure ( J:33193 )

♀ • parous females fail to lactate

reproductive system

abnormal mammary gland growth during pregnancy ( J:33193 )

♀ • gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands

♀ • pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds

♀ • acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina

♀ • in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund

♀ • however, mammary ductal growth is unaffected in virgin females

neoplasm

increased mammary adenocarcinoma incidence ( J:33193 )

• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months

increased lung tumor incidence ( J:33193 )

• most tumor-bearing females, irrespective of breeding history, develop metastatic lung tumors

integument

abnormal mammary gland growth during pregnancy ( J:33193 )

♀ • gestating females exhibit abnormal development of secretory lobules such that during late pregnancy, lobular development is severely retarded, and no secretory activity is apparent in the glands

♀ • pregnant and postpartum mammary glands show dysplastic ducts and poorly formed alveolar buds

♀ • acini in day 1 postpartum lactating glands have small lumina, constricted by numerous nonpolar, undifferentiated epithelial cells, which contain little or no endoplasmic reticulum, secretory vesicles, or lipid droplets and no secretory particles are present in acinar lumina

♀ • in ducts of postpartum females, the luminal epithelial cells appear condensed and moribund

♀ • however, mammary ductal growth is unaffected in virgin females

increased mammary adenocarcinoma incidence ( J:33193 )

• all virgin and multiparous females develop mammary tumors, with a 50% incidence of tumors in virgins at 11 months of age and in breeding females at 5 months

lactation failure ( J:33193 )

♀ • parous females fail to lactate

respiratory system

increased lung tumor incidence ( J:33193 )

• most tumor-bearing females, irrespective of breeding history, develop metastatic lung tumors