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Phenotypes Associated with This Genotype
Genotype
MGI:3712442
Allelic
Composition		 Irf4tm1Rdf/Irf4tm1.1Rdf
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf4tm1.1Rdf mutation (0 available); any Irf4 mutation (34 available)
Irf4tm1Rdf mutation (1 available); any Irf4 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:112643 )
• mature B cells treated with TAT-cre to achieve in vitro deletion of Irf4 are unable to differentiate into plasma cells after LPS treatment, suggesting that it is not a consequence of the developmental stage of the B cells in mutants vs wild-type

hematopoietic system
abnormal B cell physiology ( J:112643 )
• mature B cells treated with TAT-cre to achieve in vitro deletion of Irf4 are unable to differentiate into plasma cells after LPS treatment, suggesting that it is not a consequence of the developmental stage of the B cells in mutants vs wild-type

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory