Phenotypes Associated with This Genotype

Genotype
MGI:3712438

• Allelic Composition: Irf4^tm1.1Rdf/Irf4^tm1.1Rdf
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:112643 )

• mice have decreased percentages of IgD+, CD23+, and PNA+ B cells compared to controls

absent spleen germinal center ( J:112643 )

• complete absence of germinal centers in spleen

abnormal B cell physiology ( J:112643 )

• in culture, B cells treated with LPS to induce plasmablastic differentiation do not differentiate, whereas wild-type B cells do

decreased B cell proliferation ( J:112643 )

• rate is slower than wild-type cells

decreased IgG1 level ( J:112643 )

• percentage of cells expressing IgG1 after stimulation with CD40 plus Il-4 is much lower than in wild-type cultures after same number of cell divisions

hematopoietic system

abnormal B cell differentiation ( J:112643 )

• mice have decreased percentages of IgD+, CD23+, and PNA+ B cells compared to controls

absent spleen germinal center ( J:112643 )

• complete absence of germinal centers in spleen

abnormal B cell physiology ( J:112643 )

• in culture, B cells treated with LPS to induce plasmablastic differentiation do not differentiate, whereas wild-type B cells do

decreased B cell proliferation ( J:112643 )

• rate is slower than wild-type cells

decreased IgG1 level ( J:112643 )

• percentage of cells expressing IgG1 after stimulation with CD40 plus Il-4 is much lower than in wild-type cultures after same number of cell divisions

cellular

decreased B cell proliferation ( J:112643 )

• rate is slower than wild-type cells