immune system
• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
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• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
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• both Peyer's patches and mesenteric lymph nodes have a decrease in germinal center B cells
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• contains less germinal center B Cells
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• antibody response to NP-CGG is reduced to about one fifth
• however, splenic germinal center B cell numbers are comparable to those in a normal response
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• under in vitro conditions that promote does not any differentiation pathway, interferon gamma production is reduced
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• under in vitro conditions that promote does not any differentiation pathway IL-10 production is increased
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• under in vitro conditions that promote does not any differentiation pathway, IL-4 production is reduced
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• following BCR activation, B cells produce less TNF
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hematopoietic system
• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
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• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
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