Phenotypes Associated with This Genotype

Genotype
MGI:3711913

• Allelic Composition: Gli3^tm2Blnw/Gli3⁺; Shh^tm1Chg/Shh^tm1Chg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal limb morphology ( J:121609 )

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal autopod morphology ( J:121609 )

• digit identity is partially restored with 3 or 4 digits clearly mimicking digits 2 to 4 or 2 to 5 identities

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal digit morphology ( J:121609 )

• limb phenotypes are indistinguishable to those seen in Gli3^tm2Blnw homozygotes

abnormal phalanx morphology ( J:121609 )

• some digits have shortened phalanges

polydactyly ( J:121609 )

• digit 1 is sometimes duplicated

absent tibia ( J:121609 )

short tibia ( J:121609 )

skeleton

abnormal phalanx morphology ( J:121609 )

• some digits have shortened phalanges

absent tibia ( J:121609 )

short tibia ( J:121609 )

synostosis ( J:121609 )