Phenotypes Associated with This Genotype

Genotype
MGI:3711878

• Allelic Composition: Gas1^tm2Fan/Gas1^tm2Fan; Shh^tm1Chg/Shh^tm1Chg
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121554 )

• mice die after E9.5 and are all dead at E13.5

embryo

abnormal embryo turning ( J:121554 )

• at E9.5, embryos fail to undergo proper turning

abnormal rostral-caudal body axis extension ( J:121554 )

• at E9.5, double-kink in the body axis or an L-shaped body axis

embryonic growth arrest ( J:121554 )

• development arrests at E9.5

decreased embryo size ( J:121554 )

• at E9.5

growth/size/body

decreased embryo size ( J:121554 )

• at E9.5

cardiovascular system

abnormal heart tube morphology ( J:121554 )

• at E9.5, hearts are linear or mostly linear

enlarged pericardium ( J:121554 )

• at E9.5

homeostasis/metabolism

cardiac edema ( J:121554 )

• at E9.5, severe cardiac edema