Phenotypes Associated with This Genotype

Genotype
MGI:3711858

• Allelic Composition: Tcrb^tm2Slek/Tcrb^tm2Slek; Trbv13-2^tm1(CD2)Zhu/Trbv13-2^tm1(CD2)Zhu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:121608 )

• human CD2 expression (germline transcription from the Vbeta8.2 promoter) is higher in cells expressing Vbeta genes downstream of Vbeta8.2 promoter, whereas no CD2 expression is detected from T cells using V genes upstream of Vbeta8.2

immune system

abnormal T cell differentiation ( J:121608 )

• human CD2 expression (germline transcription from the Vbeta8.2 promoter) is higher in cells expressing Vbeta genes downstream of Vbeta8.2 promoter, whereas no CD2 expression is detected from T cells using V genes upstream of Vbeta8.2