Phenotypes Associated with This Genotype

Genotype
MGI:3711857

• Allelic Composition: Trbv13-2^tm1(CD2)Zhu/Trbv13-2^tm1(CD2)Zhu
• Genetic Background: involves: 129 * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:121608 )

• Background Sensitivity: in B6/SJL F1 mice, transcript levels for Vbeta5.1, Vbeta8.2, and Vbeta12 are half that seen in 129/B6 mutants which have bi-allelic expression, indicating transcription correlates with number of alleles present; the Vbeta gene in SJL mice contains an 80 kp deletion from Vbeta5.2-9

immune system

abnormal T cell differentiation ( J:121608 )

• Background Sensitivity: in B6/SJL F1 mice, transcript levels for Vbeta5.1, Vbeta8.2, and Vbeta12 are half that seen in 129/B6 mutants which have bi-allelic expression, indicating transcription correlates with number of alleles present; the Vbeta gene in SJL mice contains an 80 kp deletion from Vbeta5.2-9