Phenotypes Associated with This Genotype

Genotype
MGI:3711709

• Allelic Composition: Tg(APPSWE)2576Kha/?; Tg(PDGFB-PSEN1M146L)2Jhd/?
• Genetic Background: involves: C57BL/6 * DBA/2 * SJL * SW

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

gliosis ( J:80429 )

• microgliosis and astrocytosis reduced in the hippocampus, and entorhinal cortex

• astrocytosis also reduced in the cingulated cortex

amyloid beta deposits ( J:80429 )

• treatment with antibody to CD40L results in more diffuse beta-amyloid plaques

• equal levels of alpha- and beta-CTF

• antibody to CD40L produces increased levels of circulating beta amyloid

homeostasis/metabolism

amyloid beta deposits ( J:80429 )

• treatment with antibody to CD40L results in more diffuse beta-amyloid plaques

• equal levels of alpha- and beta-CTF

• antibody to CD40L produces increased levels of circulating beta amyloid

cellular

gliosis ( J:80429 )

• microgliosis and astrocytosis reduced in the hippocampus, and entorhinal cortex

• astrocytosis also reduced in the cingulated cortex