Mouse Genome Informatics
ot
    EdaTa/Y
involves: A * C57BL * CBA * RIII
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye

endocrine/exocrine glands
• lack palmar and volar sweat glands
• exhibit anhidrosis

respiratory system
• unable to keep nasal cavities clear,impairing air flow causing "snuffling"
• male mice lack submucosal glands

pigmentation

limbs/digits/tail
• dermal ridges on the paws are absent in all adults; EGF injection postnatally can induce dermal ridge and sweat gland formation
• lack palmar and volar sweat glands
• usually there are multiple sharp kinks at the tail tip (J:249)
(J:12999)

skeleton

craniofacial
(J:5018)
(J:12999)
• often absent
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger
• molars have 1-2 composite roots instead of the usual three roots
• crown of molars shows a simplified cusp pattern
• third molar is often absent (J:5018)
(J:12999)
• molars are usually smaller than normal
• increase in enamel cover of the incisors
• unable to keep nasal cavities clear,impairing air flow causing "snuffling"

integument
• lack palmar and volar sweat glands
• exhibit anhidrosis
• hair does not develop behind the ears or on the tail (J:249)
(J:12999)
(J:249)
(J:12999)
(J:249)
(J:12999)
• usually one rather than two supra-orbital vibrissa
• post-orbital sinus follicle and vibrissa are absent

growth/size/body
(J:5018)
(J:12999)
• often absent
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger
• molars have 1-2 composite roots instead of the usual three roots
• crown of molars shows a simplified cusp pattern
• third molar is often absent (J:5018)
(J:12999)
• molars are usually smaller than normal
• increase in enamel cover of the incisors
• unable to keep nasal cavities clear,impairing air flow causing "snuffling"

Mouse Models of Human Disease
OMIM IDRef(s)
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked; XHED 305100 J:42660