Mouse Genome Informatics
ot
    EdaTa/Y
involves: A * C57BL * CBA * RIII
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
vision/eye

endocrine/exocrine glands
• lack palmar and volar sweat glands (J:42660)
• exhibit anhidrosis (J:42660)

respiratory system
• unable to keep nasal cavities clear,impairing air flow causing "snuffling" (J:249)
• male mice lack submucosal glands (J:119848)

pigmentation

limbs/digits/tail
• dermal ridges on the paws are absent in all adults; EGF injection postnatally can induce dermal ridge and sweat gland formation (J:42660)
• lack palmar and volar sweat glands (J:42660)
• usually there are multiple sharp kinks at the tail tip (J:249)
(J:12999)

skeleton

craniofacial
(J:5018)
(J:12999)
• often absent (J:5018)
(J:5018)
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones (J:12999)
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger (J:12999)
• molars have 1-2 composite roots instead of the usual three roots (J:12999)
• crown of molars shows a simplified cusp pattern (J:12999)
• third molar is often absent (J:5018)
(J:12999)
• molars are usually smaller than normal (J:5018)
• increase in enamel cover of the incisors (J:12999)
• unable to keep nasal cavities clear,impairing air flow causing "snuffling" (J:249)

integument
• lack palmar and volar sweat glands (J:42660)
• exhibit anhidrosis (J:42660)
• hair does not develop behind the ears or on the tail (J:249)
(J:12999)
(J:249)
(J:12999)
(J:249)
(J:12999)
• usually one rather than two supra-orbital vibrissa (J:249)
• post-orbital sinus follicle and vibrissa are absent (J:249)

growth/size/body
(J:5018)
(J:12999)
• often absent (J:5018)
(J:5018)
• molars are abnormal; abnormalities of the upper molars are less variable than those of the lower ones (J:12999)
• molars are variable in size, sometimes smaller or larger than in wild-type, depending on the size of the first molar; if the first molar is only slightly smaller, the rest of the molars are smaller, if it is much smaller, than the other molars tend to be larger (J:12999)
• molars have 1-2 composite roots instead of the usual three roots (J:12999)
• crown of molars shows a simplified cusp pattern (J:12999)
• third molar is often absent (J:5018)
(J:12999)
• molars are usually smaller than normal (J:5018)
• increase in enamel cover of the incisors (J:12999)
• unable to keep nasal cavities clear,impairing air flow causing "snuffling" (J:249)

Mouse Models of Human Disease
OMIM IDRef(s)
Ectodermal Dysplasia 1, Hypohidrotic, X-Linked; XHED 305100 J:42660