Phenotypes Associated with This Genotype

Genotype
MGI:3711507

• Allelic Composition: Cxadr^tm1Mds/Cxadr^tm1Mds; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:121400 )

N • many conditional null mice are born alive and survive to adulthood (20/102)

cardiovascular system

abnormal sinoatrial valve morphology ( J:121400 )

• sinuatrial valves show mild abnormalities in embryos, with only 1 embryo showing absence or attenuation comparable to constitutive null mice

abnormal heart ventricle morphology ( J:121400 )

• embryos show only mild or no abnormal ventricular thickening with little or no increase in proliferating cells