Phenotypes Associated with This Genotype

Genotype
MGI:3711496

• Allelic Composition: Pygo2^tm1.1Ssp/Pygo2^tm1.1Ssp; Tg(Pax6-cre,GFP)1Pgr/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens induction ( J:121416 )

• beginning at E9.5, lens induction is abnormal as indicated by reduced Pax6+ cells

abnormal optic placode morphology ( J:121416 )

• at E9.5, the lens placode is thinner

abnormal lens epithelium morphology ( J:121416 )

• at E12.5, the pigmented epithelium is collapsed to the center of the eye cup

aphakia ( J:121416 )

• at E12.5, lenses were small or absent

small lens ( J:121416 )

• at E12.5, lenses were small or absent

craniofacial

small optic pit ( J:121416 )

• at E10.5, the optic pit is smaller than normal