Phenotypes Associated with This Genotype

Genotype
MGI:3711495

• Allelic Composition: Pygo2^tm1.1Ssp/Pygo2^tm1.1Ssp; Tg(CMV-cre)1Cgn/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:121416 )

• most mice die neonatally

vision/eye

aphakia ( J:121416 )

• in all day-of-birth mice lenses were small or absent

small lens ( J:121416 )

• in all day-of-birth mice lenses were small or absent

abnormal optic cup morphology ( J:121416 )

• optic cups are misshapen with abnormal retinal folds and excess mesenchyme cells

• however, retinal differentiation and retinal pigment epithelium are grossly normal

microphthalmia ( J:121416 )

renal/urinary system

abnormal kidney development ( J:121416 )

• mild kidney development defects

growth/size/body

decreased fetal size ( J:121416 )

• mice are smaller late gestation