Phenotypes Associated with This Genotype

Genotype
MGI:3711452

• Allelic Composition: Braf^tm1.1Sva/Braf^tm1.1Sva
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121660 )

• death at ~E13

embryo

embryonic growth retardation ( J:121660 )

• embryos show obvious growth retardation prior to death

growth/size/body

embryonic growth retardation ( J:121660 )

• embryos show obvious growth retardation prior to death

nervous system

increased neuron apoptosis ( J:121660 )

• ~90% of cultured DRG neurons from E12.5 embryos die within 5 days in presence of nerve growth factor compared to 19% loss of heterozygous control neurons

cellular

increased neuron apoptosis ( J:121660 )

• ~90% of cultured DRG neurons from E12.5 embryos die within 5 days in presence of nerve growth factor compared to 19% loss of heterozygous control neurons