Phenotypes Associated with This Genotype

Genotype
MGI:3711413

• Allelic Composition: Zbtb7a^tm1Ppp/Zbtb7a^tm1Ppp
• Genetic Background: B6.129S1-Zbtb7a^tm1Ppp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:121576 )

• lethality occurs at 16.5 days post coitum (dpc)

hematopoietic system

hematopoietic system phenotype ( J:121576 )

N • hematopoietic stem cell (HSC) and common lyphoid progenitor (CLP) populations are normal

abnormal lymphopoiesis ( J:121576 )

• abnormal in fetal liver at 14.5 dpc

decreased pro-B cell number ( J:121576 )

• pro-B cells are barely detectable in interleukin 7-treated cultures of fetal liver HSCs compared to wild-type cultures

decreased B cell number ( J:121576 )

• at 14.5 dpc, total number of CD19+B220+ B cells is reduced

immune system

abnormal lymphopoiesis ( J:121576 )

• abnormal in fetal liver at 14.5 dpc

decreased pro-B cell number ( J:121576 )

• pro-B cells are barely detectable in interleukin 7-treated cultures of fetal liver HSCs compared to wild-type cultures

decreased B cell number ( J:121576 )

• at 14.5 dpc, total number of CD19+B220+ B cells is reduced

abnormal response to transplant ( J:121576 )

• when fetal liver cells are transplanted into irradiated recipients for bone marrow competitive repopulation assays, B cells derived from mutant livers are nearly undetectable in peripheral blood