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Phenotypes Associated with This Genotype
Genotype
MGI:3711342
Allelic
Composition
MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
Genetic
Background
B6.129P2-MtrrGt(XG334)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MtrrGt(XG334)Byg mutation (1 available); any Mtrr mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• liver AdoMet levels are increased (69.0+/-0.2uM compared to 38.0+/-4.3uM in wild-type)
• AdoHcy levels are increased in the heart (2.0+/-0.3 compared to 0.9+/-0.2 in wild-type) and in the liver in one trial but not another
• the AdoMet/AdoHcy ratio is increased in the liver (2.2+/-0.2 compared to 0.8+/-0.2 in wild-type) but decreased in the heart (18.4+/-1.4 compared to 46.9+/-7.2 in wild-type)

Mouse Models of Human Disease
OMIM ID Ref(s)
Homocysteinemia 603174 J:121477


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory