Mouse Genome Informatics
hm
    MtrrGt(XG334)Byg/MtrrGt(XG334)Byg
B6.129P2-MtrrGt(XG334)Byg
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• liver AdoMet levels are increased (69.0+/-0.2uM compared to 38.0+/-4.3uM in wild-type)
• AdoHcy levels are increased in the heart (2.0+/-0.3 compared to 0.9+/-0.2 in wild-type) and in the liver in one trial but not another
• the AdoMet/AdoHcy ratio is increased in the liver (2.2+/-0.2 compared to 0.8+/-0.2 in wild-type) but decreased in the heart (18.4+/-1.4 compared to 46.9+/-7.2 in wild-type)

Mouse Models of Human Disease
OMIM IDRef(s)
Homocysteinemia 603174 J:121477