Phenotypes Associated with This Genotype

Genotype
MGI:3711342

• Allelic Composition: Mtrr^Gt(XG334)Byg/Mtrr^Gt(XG334)Byg
• Genetic Background: B6.129P2-Mtrr^Gt(XG334)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:121477 )

• liver AdoMet levels are increased (69.0+/-0.2uM compared to 38.0+/-4.3uM in wild-type)

abnormal circulating homocysteine level ( J:121477 )

• AdoHcy levels are increased in the heart (2.0+/-0.3 compared to 0.9+/-0.2 in wild-type) and in the liver in one trial but not another

• the AdoMet/AdoHcy ratio is increased in the liver (2.2+/-0.2 compared to 0.8+/-0.2 in wild-type) but decreased in the heart (18.4+/-1.4 compared to 46.9+/-7.2 in wild-type)